The term, liver cell dysplasia, which was proposed and defined as cellular
enlargement, nuclear pleomorphism, and multinucleation of liver cells occurring in groups
or occupying whole cirrhotic nodule by Anthony et al, has been considered to be
premalignant condition.
The authors reviewed dysplasia in 247 cases with cirrhotic or cancerous livers
including non-cirrhotic and non-malignant control group, and studied the presence of
HBsAg to evaluate the relationship between HBsAg and dysplasia in cirrhosis and
hepatocellular carcinoma. The results are as follows :
1) Liver cell dysplasia was found in 6 out of 132 cases(4.5%) of control group, in 2
out of 16 cases (12.5%) with hepatocellular carcinoma,28 of 89 cases (31.5%) with
cirrhosis only, and 7 out of 10 cases (70%) with cirrhosis and hepatocellular carcinoma.
2) There were no age and sex differences between cirrhosis and cirrhosis with
hepatocellular carcinoma, with or without dysplasia.
3) Serum HBsAg were positive in 8 out of 12 cases(66.7%) with dysplasia, whereas
positive in 5 our of 16 cases (31.2%) without dysplasia.
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